hominis, but eye contamination or insect bite (as mimicked by injection) are suggested as possible routes of infection under natural conditions. Natural killer (NK) cell-deficient mice are useful models in biomedical research. Peroral infection seems to be ineffective in T. hominis has very little tissue specificity. The humanized SRC-SCID model is established by injecting newborn or adult immunodeficient mice with HSCs from a variety of sources and has been regarded as a.
Infection was not detected in the brain of any of the inoculated SCID mice. The SCID mice, inoculated perorally and examined after 23 weeks, were uninfected. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. Intraperitoneally inoculated SCID mice survived for 13 weeks and the urinary bladder and liver were the most heavily infected organs. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. Intracerebrally inoculated SCID mice became moribund 5 or 6 weeks after inoculation with massive infection in the urinary bladder and liver, but none in the brain.
SCID MOUSE SKIN
Subcutaneously inoculated SCID mice developed skin lesions around the inoculation sites, and heavy urinary bladder infection, and died 6 or 7 weeks after inoculation. Xenografts of human tumor tissue into immunocompromised mice can provide a more accurate model of tumor growth and activity of administered drugs than in vitro. To measure the pharmacokinetics of baricitinib in the mouse brain and plasma, the drug was administered SC to SCID mice (n 3 for each time point). The mean survival time of intramuscularly inoculated SCID mice was 12 weeks, when heavy infection was found in muscles around the site of inoculation, and also in several viscera. Quantification of baricitinib in the murine brain and drug dosing calculations. After eye contamination by spores the mice became moribund within 7 to 8 weeks, showing severe infection in the conjunctiva and cornea, and lighter infections in the urinary bladder, liver and spleen. Different courses of microsporidiosis, related to the route of infection, were observed in severe combined immunodeficient (SCID) mice inoculated with spores of the human microsporidian Trachipleistophora hominis (Phylum Microspora).
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